Keratrate is a penetration enhancer for ungual (under the nail) drug delivery, comprised of a keratinase enzyme and a powerful reducing agent that enhances the ability of the enzyme. One of the primary reasons that most treatments for toenail fungus are unsuccessful is due to the inability of the antifungal medication to reach the nail bed where the infection is.

Finger and Toe nails are good at keeping out external substances, that’s how they were designed. Nails are made from a substance called keratin, which is a very fiberous type of protein.  Human skin, hair and nails are all made of keratin but the ones making up the nails are different and much harder and woven together more tightly.  This makes it very difficult for any medication to actually penetrate the nail itself and so most place the medication on the surrounding skin and hope some is absorbed.

Keratrate works by doing three things. First, it uses a special enzyme called keratinase that dissolves the dense protein bonds in keratin that make up the hardened nail plate. Secondly, it uses a selective reducing agent to further break the tight knit disulfide bonds that make up proteins. Finally, we use what is called a chaotropic agent in order to disrupt the ability of the proteins to reform. The net effect of this is that after the application of FixaFungus pre-treatment with Keratrate to the nail, the very structure of the nail will be changed in order to make it easier for the antifungal drugs like Fungicillin to penetrate to the nail bed below.

In most cases, when using our Toenail Fungus Treatment pre-treatment with Keratrate, you will not notice any significant visible change to the nail except that the finish will likely change from a glossy shine to a slightly dull matte or flat look. The reason for that change is that the Keratrate has made the top of the nail plate jagged instead of the smooth connected surface it normally is. This allows the antifungal treatment to penetrate to the nail bed and to kill the fungus.

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